APOE anticorps (N-Term)

N° du produit ABIN2785631

Cet anticorps Lapin Polyclonal détecte spécifiquement APOE dans WB et IHC. Il présente une réactivité envers Humain, Souris, Rat et Poisson zèbre (Danio rerio).

Aperçu rapide pour APOE anticorps (N-Term) (ABIN2785631)

Antigène: APOE (Apolipoprotein E (APOE))

Reactivité: Humain, Souris, Rat, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp APOE est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-APOE anticorps

Épitope: N-Term

Séquence: LMDETMKELK AYKSELEEQL TPVAEETRAR LSKELQAAQA RLGADMEDVC

Homologie: Human: 100%, Mouse: 93%, Rat: 93%, Zebrafish: 77%

Attributs du produit: This is a rabbit polyclonal antibody against APOE. It was validated on Western Blot.

Purification: Affinity Purified

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 317 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur APOE

Antigène: APOE (Apolipoprotein E (APOE))

Autre désignation: APOE

Sujet: Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
Alias Symbols: AD2, LDLCQ5, LPG, MGC1571
Protein Interaction Partner: LCAT, ARFGAP1, ALB, C19orf52, LOXL4, PRAM1, MID1IP1, ANKH, FBXL12, FXYD7, ECSIT, PDCD4, IFIT5, MAST1, EPN2, PLEKHA6, CDC37, IQSEC1, LONP1, TYRO3, PRDX2, ST13, RPL4, RHEB, PSEN1, HTRA1, PCMT1, ZNF558, NOS3, IFIT3, GCDH, FOXG1, FARSA, ELAVL1, CYP2C18, CYP2C
Protein Size: 317

Poids moléculaire: 34 kDa

ID gène: 348

NCBI Accession: NM_000041, NP_000032

UniProt: P02649

Pathways: Regulation of Cell Size, Lipid Metabolism