Gelsolin anticorps (C-Term)

N° du produit ABIN2785642

Cet anticorps Lapin Polyclonal détecte spécifiquement Gelsolin dans WB et IHC. Il présente une réactivité envers Humain, Rat, Souris, Boeuf (Vache), Lapin, Chien, Cheval, Mouton, Poisson zèbre (Danio rerio) et Cobaye et a été mentionné dans 1 publication.

Aperçu rapide pour Gelsolin anticorps (C-Term) (ABIN2785642)

Antigène: Gelsolin (GSN)

Reactivité: Humain, Rat, Souris, Boeuf (Vache), Lapin, Chien, Cheval, Mouton, Poisson zèbre (Danio rerio), Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Gelsolin est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-Gelsolin anticorps

Épitope: C-Term

Séquence: KPMIIYKGGT SREGGQTAPA STRLFQVRAN SAGATRAVEV LPKAGALNSN

Homologie: Cow: 100%, Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 100%, Sheep: 100%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against GSN. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human GSN

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 782 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-Gelsolin (ABIN2785642)

Shokouhi, Khosroshahi: "Ardalan-Shoja-Kiuru syndrome--hereditary gelsolin amyloidosis plus retinitis pigmentosa." dans: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, Vol. 23, Issue 3, pp. 1071; author reply 1071-2, (2008) (PubMed).

Détails sur Gelsolin

Antigène: Gelsolin (GSN)

Autre désignation: GSN

Sujet: GSN binds to the 'plus' ends of actin monomers and filaments to prevent monomer exchange. It is a calcium-regulated protein, which functions in both assembly and disassembly of actin filaments. Defects in the gene encoding GSN are a cause of familial amyloidosis Finnish type (FAF).The protein encoded by this gene binds to the 'plus' ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene.
Alias Symbols: DKFZp313L0718, ADF, AGEL
Protein Interaction Partner: ITCH, CFLAR, TP53, UBC, CASP3, UBD, FN1, MPG, ESR1, ALB, SDHB, ACTA1, MDM2, UBE2Q2, FBXO25, ARRB2, ARRB1, AR, PSMD4, TNIK, CLIC5, TOM1L1, ACTN4, VDAC1, BCAR1, PXN, LIMK2, VASP, PIK3CG, PTK2B, FHIT, VCL, CSK, APP, ACTB, ACTG1, PLCG1, SRC, PTPN12, PTK2, PIK
Protein Size: 782

Poids moléculaire: 83 kDa

ID gène: 2934

NCBI Accession: NM_000177, NP_000168

UniProt: P06396

Pathways: Caspase Cascade in Apoptosis, Regulation of Actin Filament Polymerization, Autophagy