IMPDH2 anticorps (C-Term)

N° du produit ABIN2785674

L’anticorps anti-IMPDH2 Polyclonal Lapin est utilisé pour la détection de IMPDH2 dans des échantillons de Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin, Poisson zèbre (Danio rerio) et Saccharomyces cerevisiae. Il a été validé pour WB.

Aperçu rapide pour IMPDH2 anticorps (C-Term) (ABIN2785674)

Antigène: IMPDH2 (IMP (Inosine 5'-Monophosphate) Dehydrogenase 2 (IMPDH2))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin, Poisson zèbre (Danio rerio), Saccharomyces cerevisiae

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IMPDH2 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-IMPDH2 anticorps

Épitope: C-Term

Séquence: SCQDIGAKSL TQVRAMMYSG ELKFEKRTSS AQVEGGVHSL HSYEKRLF

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 92%, Zebrafish: 93%

Attributs du produit: This is a rabbit polyclonal antibody against IMPDH2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human IMPDH2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 514 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur IMPDH2

Antigène: IMPDH2 (IMP (Inosine 5'-Monophosphate) Dehydrogenase 2 (IMPDH2))

Autre désignation: IMPDH2

Sujet: IMPDH2 is the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. It catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. IMPDH2 is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: IMPD2, IMPDH-II
Protein Interaction Partner: RSG1, APIP, HUWE1, UBC, IMPDH2, CDK2, RPA1, RPA3, RPA2, PRKAR2A, IMPDH1, EIF2S3, PARK2, MAPK10, SOX2, NPM1, PEX14, FN1, RPLP0P6, RPS6, RPL15, FOLR1, FBXO6, GRB2, UBQLN4, PIAS4, COPS5, COPS6, CUL3, YWHAZ, FBXO25, SIRT7, HDAC5, MME, SUMO4, AKT1, IKBKE, ATG5
Protein Size: 514

Poids moléculaire: 56 kDa

ID gène: 3615

NCBI Accession: NM_000884, NP_000875

UniProt: P12268

Pathways: Ribonucleoside Biosynthetic Process, SARS-CoV-2 Protein Interactome