GALE anticorps (Middle Region)

N° du produit ABIN2785691

L’anticorps Lapin Polyclonal anti-GALE a été validé pour WB. Il convient pour détecter GALE dans des échantillons de Humain, Rat, Chien, Boeuf (Vache), Porc, Lapin et Cheval.

Aperçu rapide pour GALE anticorps (Middle Region) (ABIN2785691)

Antigène: GALE (UDP-Galactose-4-Epimerase (GALE))

Reactivité: Humain, Rat, Chien, Boeuf (Vache), Porc, Lapin, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GALE est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-GALE anticorps

Épitope: Middle Region

Séquence: PQGIPNNLMP YVSQVAIGRR EALNVFGNDY DTEDGTGVRD YIHVVDLAKG

Homologie: Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Pig: 100%, Rabbit: 100%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against GALE. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human GALE

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 348 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur GALE

Antigène: GALE (UDP-Galactose-4-Epimerase (GALE))

Autre désignation: GALE

Sujet: GALE is an UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and mental retardation, with symptoms ranging from mild ('peripheral' form) to severe ('generalized' form).
Alias Symbols: SDR1E1
Protein Interaction Partner: GALE, SUMO2, UBC, BAG3, FN1, APP,
Protein Size: 348

Poids moléculaire: 38 kDa

ID gène: 2582

NCBI Accession: NM_001008216, NP_001008217

UniProt: Q14376

Pathways: Response to Water Deprivation, Cellular Glucan Metabolic Process