Ubiquilin 1 anticorps (Middle Region)

N° du produit ABIN2785977

Détail du produit anti-Ubiquilin 1 anticorps

Antigène: Ubiquilin 1 (UBQLN1)

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Cheval, Lapin, Mouton, Boeuf (Vache), Chien, Cobaye, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Ubiquilin 1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: QFGGNPFASL VSNTSSGEGS QPSRTENRDP LPNPWAPQTS QSSSASSGTA

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 92%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 79%

Attributs du produit: This is a rabbit polyclonal antibody against UBQLN1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human UBQLN1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 589 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur Ubiquilin 1

Antigène: Ubiquilin 1 (UBQLN1)

Autre désignation: UBQLN1 (UBQLN1 Produits)

Sujet: UBQLN1 is an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and it is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene.This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: DA41, DSK2, FLJ90054, PLIC-1, XDRP1, UBQN
Protein Interaction Partner: MLLT6, MCM7, IL6ST, IGLC1, IGL, SLC29A2, HK2, GYPB, GRM2, GPX3, GABRD, FN1, FKBP2, FCGR2A, DEFA6, CTAG1B, CSTF2, COL10A1, COL1A2, CALU, IGLV2-14, FAM127B, CSTF2T, FAM127C, TMEM31, AGR3, ITPRIPL1, TRIM32, ACOT7, PLA2G16, SMR3B, AGR2, PSMD6, NUPL1, IST1, LI
Protein Size: 589

Poids moléculaire: 62 kDa

ID gène: 29979

NCBI Accession: NM_013438, NP_038466

UniProt: Q5T6J9