ITGB3BP anticorps (N-Term)

N° du produit ABIN2785998

L’anticorps anti-ITGB3BP Polyclonal Lapin est utilisé pour la détection de ITGB3BP dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour ITGB3BP anticorps (N-Term) (ABIN2785998)

Antigène: ITGB3BP (Integrin beta 3 Binding Protein (Beta3-Endonexin) (ITGB3BP))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ITGB3BP est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-ITGB3BP anticorps

Épitope: N-Term

Fonction: ITGB3BP Antibody - N-terminal region

Séquence: TGTCQMSLFA SPTSSEEQKH RNGLSNEKRK KLNHPSLTES KESTTKDNDE

Homologie: Human: 100%

Attributs du produit: This is a rabbit polyclonal antibody against ITGB3BP. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human ITGB3BP

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP54999-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur ITGB3BP

Antigène: ITGB3BP (Integrin beta 3 Binding Protein (Beta3-Endonexin) (ITGB3BP))

Autre désignation: ITGB3BP

Sujet:

Background Information: ITGB3BP is a transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. ITGB3BP acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. It induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. ITGB3BP may also act as an inhibitor of cyclin A-associated kinase. ITGB3BP may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.

Gene Name: Integrin beta 3 binding protein (beta3-endonexin)

Alternative Symbols: CENPR, NRIF3, TAP20, CENP-R, HSU37139

Protein Name: Centromere protein R

Poids moléculaire: 20kDa

ID gène: 23421

NCBI Accession: NP_055103

UniProt: Q13352

Pathways: Neurotrophin Signaling Pathway