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ITGB3BP anticorps (N-Term)

ITGB3BP Reactivité: Humain WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2785998
  • Antigène Voir toutes ITGB3BP Anticorps
    ITGB3BP (Integrin beta 3 Binding Protein (Beta3-Endonexin) (ITGB3BP))
    Épitope
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 22
    • 4
    • 3
    • 1
    • 1
    Humain
    Hôte
    • 20
    • 2
    Lapin
    Clonalité
    • 20
    • 2
    Polyclonal
    Conjugué
    • 15
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ITGB3BP est non-conjugé
    Application
    • 11
    • 8
    • 7
    • 2
    Western Blotting (WB)
    Séquence
    TGTCQMSLFA SPTSSEEQKH RNGLSNEKRK KLNHPSLTES KESTTKDNDE
    Homologie
    Human: 100%
    Attributs du produit
    This is a rabbit polyclonal antibody against ITGB3BP. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the N terminal region of human ITGB3BP
    Top Product
    Discover our top product ITGB3BP Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 177 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Antigène
    ITGB3BP (Integrin beta 3 Binding Protein (Beta3-Endonexin) (ITGB3BP))
    Autre désignation
    ITGB3BP (ITGB3BP Produits)
    Synonymes
    anticorps CENP-R, anticorps CENPR, anticorps HSU37139, anticorps NRIF3, anticorps TAP20, anticorps 4930471O16Rik, anticorps AU022583, anticorps integrin subunit beta 3 binding protein, anticorps integrin beta 3 binding protein (beta3-endonexin), anticorps ITGB3BP, anticorps Itgb3bp
    Sujet
    ITGB3BP is a transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. ITGB3BP acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. It induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. ITGB3BP may also act as an inhibitor of cyclin A-associated kinase. ITGB3BP may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.
    Alias Symbols: CENP-R, CENPR, HSU37139, NRIF3, TAP20
    Protein Interaction Partner: PIH1D2, UBR7, ARFIP2, COL4A3BP, KIFC3, KDM1A, UBC, APP, CENPP, CENPO, SVIL, MAPK6, ACTN2, MTA1, ITGB3BP, DDX24, RECQL5, RXRA, ITGB3, NFKB1, ITGB5, ESR1, CCNA2, THRA, RELA, RXRG,
    Protein Size: 177
    Poids moléculaire
    20 kDa
    ID gène
    23421
    NCBI Accession
    NM_014288, NP_055103
    UniProt
    Q13352
    Pathways
    Neurotrophin Signaling Pathway
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