ALKBH3 anticorps (Middle Region)

N° du produit ABIN2786204

Cet anticorps Lapin Polyclonal détecte spécifiquement ALKBH3 dans WB. Il présente une réactivité avec des échantillons de Humain, Souris, Rat, Cheval, Lapin, Boeuf (Vache), Chien, Cobaye et Porc.Il a été cité dans 1 publication.

Aperçu rapide pour ALKBH3 anticorps (Middle Region) (ABIN2786204)

Antigène: ALKBH3 (AlkB, Alkylation Repair Homolog 3 (ALKBH3))

Reactivité: Humain, Souris, Rat, Cheval, Lapin, Boeuf (Vache), Chien, Cobaye, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ALKBH3 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-ALKBH3 anticorps

Épitope: Middle Region

Fonction: ALKBH3 Antibody - middle region

Séquence: EMRKKPPPEE NGDYTYVERV KIPLDHGTLL IMEGATQADW QHRVPKEYHS

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 86%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against ALKBH3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human ALKBH3

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP55429-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-ALKBH3 (ABIN2786204)

Sundheim, Vågbø, Bjørås, Sousa, Talstad, Aas, Drabløs, Krokan, Tainer, Slupphaug: "Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage." dans: The EMBO journal, Vol. 25, Issue 14, pp. 3389-97, (2006) (PubMed).

Détails sur ALKBH3

Antigène: ALKBH3 (AlkB, Alkylation Repair Homolog 3 (ALKBH3))

Autre désignation: ALKBH3

Sujet:

Background Information: The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine.The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM]. Sequence Note: removed 1 base from the 5' end that did not align to the reference genome assembly. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-1519 AB042029.1 2-1520

Gene Name: AlkB, alkylation repair homolog 3 (E. coli)

Alternative Symbols: ABH3, PCA1, DEPC1, hABH3, DEPC-1

Protein Name: Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3

Poids moléculaire: 33kDa

ID gène: 221120

NCBI Accession: NP_631917

UniProt: Q96Q83

Pathways: Réparation de l'ADN