IL-15 anticorps (N-Term)

N° du produit ABIN2786287

L’anticorps anti-IL-15 Polyclonal Lapin est utilisé pour la détection de IL-15 dans des échantillons de Humain, Rat, Souris, Lapin, Mouton, Boeuf (Vache), Cobaye, Porc, Cheval et Chien. Il a été validé pour WB.

Aperçu rapide pour IL-15 anticorps (N-Term) (ABIN2786287)

Antigène: IL-15 (IL15) (Interleukin 15 (IL15))

Reactivité: Humain, Rat, Souris, Lapin, Mouton, Boeuf (Vache), Cobaye, Porc, Cheval, Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IL-15 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-IL-15 anticorps

Épitope: N-Term

Fonction: IL15 Antibody - N-terminal region

Séquence: RISKPHLRSI SIQCYLCLLL NSHFLTEAGI HVFILGCFSA GLPKTEANWV

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%, Sheep: 100%

Attributs du produit: This is a rabbit polyclonal antibody against IL15. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human IL15

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP55616-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur IL-15

Antigène: IL-15 (IL15) (Interleukin 15 (IL15))

Autre désignation: IL15

Sujet:

Background Information: IL15 is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis.The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported.

Gene Name: Interleukin 15

Alternative Symbols: IL-15

Protein Name: Interleukin-15

Poids moléculaire: 13kDa

ID gène: 3600

NCBI Accession: NP_751914

UniProt: P40933

Pathways: Signalistation JAK/STAT, Glycosaminoglycan Metabolic Process