ERCC1 anticorps (N-Term)

N° du produit ABIN2786445

Cet anticorps Lapin Polyclonal détecte spécifiquement ERCC1 dans WB. Il présente une réactivité avec des échantillons de Humain, Souris, Rat, Chien, Cobaye et Lapin.

Aperçu rapide pour ERCC1 anticorps (N-Term) (ABIN2786445)

Antigène: ERCC1 (Excision Repair Cross Complementing Polypeptide-1 (ERCC1))

Reactivité: Humain, Souris, Rat, Chien, Cobaye, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ERCC1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-ERCC1 anticorps

Épitope: N-Term

Fonction: ERCC1 Antibody - N-terminal region

Séquence: TVDTSAQAAP QTYAEYAISQ PLEGAGATCP TGSEPLAGET PNQALKPGAK

Homologie: Dog: 86%, Guinea Pig: 79%, Human: 100%, Mouse: 85%, Rabbit: 79%, Rat: 79%

Attributs du produit: This is a rabbit polyclonal antibody against ERCC1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N-terminal region of human ERCC1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP55941-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur ERCC1

Antigène: ERCC1 (Excision Repair Cross Complementing Polypeptide-1 (ERCC1))

Autre désignation: ERCC1

Sujet:

Background Information: The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.

Gene Name: excision repair cross-complementation group 1

Alternative Symbols: UV20, COFS4, RAD10

Protein Name: DNA excision repair protein ERCC-1

Poids moléculaire: 23kDa

ID gène: 2067

NCBI Accession: NP_001159521

UniProt: P07992

Pathways: Réparation de l'ADN, Production of Molecular Mediator of Immune Response