MLH1 anticorps (N-Term)

N° du produit ABIN2786501

Cet anticorps Lapin Polyclonal détecte spécifiquement MLH1 dans WB. Il présente une réactivité envers Humain, Souris, Rat, Chien, Poisson zèbre (Danio rerio), Boeuf (Vache), Cobaye, Cheval, Lapin et Saccharomyces cerevisiae.

Aperçu rapide pour MLH1 anticorps (N-Term) (ABIN2786501)

Antigène: MLH1 (MutL Homolog 1 (MLH1))

Reactivité: Humain, Souris, Rat, Chien, Poisson zèbre (Danio rerio), Boeuf (Vache), Cobaye, Cheval, Lapin, Saccharomyces cerevisiae

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MLH1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-MLH1 anticorps

Épitope: N-Term

Séquence: MIENCLDAKS TSIQVIVKEG GLKLIQIQDN GTGIRKEDLD IVCERFTTSK

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 83%, Zebrafish: 79%

Attributs du produit: This is a rabbit polyclonal antibody against MLH1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human MLH1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 756 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur MLH1

Antigène: MLH1 (MutL Homolog 1 (MLH1))

Autre désignation: MLH1

Sujet: This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC.This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Alternatively spliced transcript variants encoding different isoforms have been described, but their full-length natures have not been determined. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: COCA2, FCC2, HNPCC, HNPCC2, MGC5172, hMLH1
Protein Interaction Partner: SPERT, CXorf57, PSMA1, MYOG, MSH3, KPNA2, MLH3, ZC3H11A, EXO1, PMS2, MMS19, PCNA, DES, CTSB, ATF2, CKB, CAPN5, ASS1, TRIM23, ARAF, APRT, ANXA6, ANXA2, ALDOA, ACTG2, ACTG1, TXN2, GABARAP, EXOC3, CKAP4, AGR2, ZER1, NDRG1, AIFM1, SELENBP1, SQSTM1, FCGBP, ABC
Protein Size: 756

Poids moléculaire: 84 kDa

ID gène: 4292

NCBI Accession: NM_000249, NP_000240

UniProt: P40692

Pathways: Réparation de l'ADN, Production of Molecular Mediator of Immune Response