PMS2 anticorps (Middle Region)
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- Antigène Voir toutes PMS2 Anticorps
- PMS2 (PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2))
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Épitope
- Middle Region
- Reactivité
- Humain, Rat, Boeuf (Vache), Cobaye, Chien, Cheval, Lapin, Saccharomyces cerevisiae
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp PMS2 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- INKKVVPLDF SMSSLAKRIK QLHHEAQQSE GEQNYRKFRA KICPGENQAA
- Homologie
- Cow: 85%, Dog: 92%, Guinea Pig: 100%, Horse: 92%, Human: 100%, Rabbit: 92%, Rat: 92%, Yeast: 91%
- Attributs du produit
- This is a rabbit polyclonal antibody against PMS2. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the middle region of human PMS2
- Top Product
- Discover our top product PMS2 Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 862 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- PMS2 (PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2))
- Autre désignation
- PMS2 (PMS2 Produits)
- Synonymes
- anticorps HNPCC4, anticorps PMS2CL, anticorps PMSL2, anticorps AW555130, anticorps Pmsl2, anticorps PMS1 homolog 2, mismatch repair system component, anticorps PMS1 homolog2, mismatch repair system component, anticorps mismatch repair endonuclease PMS2, anticorps PMS2, anticorps Pms2, anticorps LOC463257, anticorps LOC107984056
- Sujet
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PMS2 is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors.This gene is one of the PMS2 gene family members found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants have been observed for this gene.
Alias Symbols: HNPCC4, PMS2CL, PMSL2
Protein Interaction Partner: UBC, MLH1, PCNA, PMS2P1, NSF, MSH2, LMNA, MSH6, SPRTN, BRIP1, FAN1, CLSPN, TOPBP1, PSD2, MMS19, ATAD3A, NSUN2, UBR5, COPG2, PSD3, COPG1, RUVBL2, EXO1, AIFM1, RUVBL1, XPO1, SMARCA4, RFC2, PSMD5, PSMC6, PSMC3, PSMC2, PSMC1, PRKDC, PPP2CA, PIK3C2A, MSH3, MCM
Protein Size: 862 - Poids moléculaire
- 96 kDa
- ID gène
- 5395
- NCBI Accession
- NM_000535, NP_000526
- UniProt
- P54278
- Pathways
- Réparation de l'ADN, Production of Molecular Mediator of Immune Response
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