MBP anticorps (Middle Region)

N° du produit ABIN2786585

Détail du produit anti-MBP anticorps

Antigène: MBP (Myelin Basic Protein (MBP))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Lapin, Cobaye, Chien, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MBP est non-conjugé

Application: Western Blotting (WB)

Séquence: FKDRPSESDE LQTIQEDSAA TSESLDVMAS QKRPSQRHGS KYLATASTMD

Homologie: Cow: 79%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 86%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against MBP. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human MBP

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 304 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur MBP

Antigène: MBP (Myelin Basic Protein (MBP))

Autre désignation: Myelin basic protein (MBP Produits)

Synonymes: anticorps C76307, anticorps Hmbpr, anticorps R75289, anticorps golli-mbp, anticorps mld, anticorps shi, anticorps Mbps, anticorps cb274, anticorps fj33b11, anticorps mbp, anticorps wu:fj33b11, anticorps wu:fq15b02, anticorps zgc:136630, anticorps MGC115135, anticorps myelin basic protein, anticorps myelin basic protein a, anticorps myelin basic protein L homeolog, anticorps MBP, anticorps Mbp, anticorps mbpa, anticorps mbp, anticorps mbp.L

Sujet: The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. MBP induces T-cell proliferation.The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called 'Golli-MBP') that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.
Alias Symbols: MGC99675
Protein Interaction Partner: CTDSP1, MAP3K3, UBC, PRKCB, MAPK3, MAPK1, ULK1, SQSTM1, PKN1, HIPK2, MNAT1, CDK9, CDK8, CDK7, CCNT1, CCNH, CCNC, MELK, DDX58, MAPK14, AT4G38520, AT4G31860, AT4G28400, ABI1, RPS6KA6, TOPP8, AT5G24940, AT5G10740, AT5G06750, AT3G17250, AT3G02750, AT3G15260,
Protein Size: 304

Poids moléculaire: 33 kDa

ID gène: 4155

NCBI Accession: NM_001025101, NP_001020272

UniProt: P02686