Nemo-Like Kinase anticorps (Middle Region)

N° du produit ABIN2786944

Cet anticorps anti-Nemo-Like Kinase Polyclonal Lapin (ABIN2786944) détecte spécifiquement Nemo-Like Kinase dans WB. L’anticorps est réactif avec des échantillons de Humain, Souris, Rat, Boeuf (Vache), Cobaye, Cheval, Chien, Lapin et Poisson zèbre (Danio rerio).

Aperçu rapide pour Nemo-Like Kinase anticorps (Middle Region) (ABIN2786944)

Antigène: Nemo-Like Kinase (NLK)

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Cobaye, Cheval, Chien, Lapin, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Nemo-Like Kinase est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Nemo-Like Kinase anticorps

Épitope: Middle Region

Fonction: NLK Antibody - middle region

Séquence: RLRYHTCMCK CCFSTSTGRV YTSDFEPVTN PKFDDTFEKN LSSVRQVKEI

Homologie: Cow: 100%, Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 93%

Attributs du produit: This is a rabbit polyclonal antibody against NLK. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human NLK

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP56863-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur Nemo-Like Kinase

Antigène: Nemo-Like Kinase (NLK)

Autre désignation: NLK

Sujet:

Background Information: NLK has a role in cell fate determination, required for differentiation of bone marrow stromal cells. NLK acts downstream of MAP3K7 and HIPK2 to negatively regulate the canonical Wnt/beta-catenin signaling pathway and the phosphorylation and destruction of the MYB transcription factor. NLK may suppress a wide range of transcription factors by phosphorylation of the coactivator, CREBBP By similarity.NLK is involved in TGFbeta-mediated mesoderm induction, acting downstream of MAP3K7/TAK1 to phosphorylate STAT3.

Gene Name: Nemo-like kinase

Alternative Symbols: DKFZp761G1211, FLJ21033

Protein Name: Serine/threonine-protein kinase NLK

Poids moléculaire: 58kDa

ID gène: 51701

NCBI Accession: NP_057315

UniProt: Q9UBE8

Pathways: Ubiquitin Proteasome Pathway