TBC1D7 anticorps (C-Term)

N° du produit ABIN2786978

Détail du produit anti-TBC1D7 anticorps

Antigène: TBC1D7 (TBC1 Domain Family, Member 7 (TBC1D7))

Épitope: C-Term

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Chévre, Cobaye, Cheval, Lapin, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TBC1D7 est non-conjugé

Application: Western Blotting (WB)

Séquence: ISRCFVKQLN NKYRDALPQL PKAFEQYLNL EDSRLLSHLK TCSAVSKLPY

Homologie: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against Tbc1d7. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C-terminal region of Mouse Tbc1d7

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 293 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur TBC1D7

Antigène: TBC1D7 (TBC1 Domain Family, Member 7 (TBC1D7))

Autre désignation: Tbc1d7 (TBC1D7 Produits)

Synonymes: anticorps PIG51, anticorps TBC7, anticorps dJ257A7.3, anticorps 2610009C09Rik, anticorps TBC1 domain family member 7, anticorps TBC1 domain family, member 7, anticorps TBC1D7, anticorps Tbc1d7

Sujet: Tbc1d7 is a component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is unclear whether TBC1D7 acts as a GTPase-activating protein and additional studies are required to answer this question.
Alias Symbols: 2610009C09Rik
Protein Interaction Partner: Ywhae,
Protein Size: 293

Poids moléculaire: 32 kDa

ID gène: 67046

NCBI Accession: NM_025935, NP_080211

UniProt: Q9D0K0