PIDD anticorps (Middle Region)

N° du produit ABIN2787144

L’anticorps Lapin Polyclonal anti-PIDD a été validé pour WB. Il convient pour détecter PIDD dans des échantillons de Humain, Rat, Souris, Cobaye, Boeuf (Vache) et Chien.

Aperçu rapide pour PIDD anticorps (Middle Region) (ABIN2787144)

Antigène: PIDD (P53-Induced Death Domain Protein (PIDD))

Reactivité: Humain, Rat, Souris, Cobaye, Boeuf (Vache), Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PIDD est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-PIDD anticorps

Épitope: Middle Region

Séquence: RRDPEQVLLQ CLPRNKVDAT LRRLLERYRG PEPSDTVEMF EGEEFFAAFE

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 100%, Human: 100%, Mouse: 86%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against LRDD. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human LRDD

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 753 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur PIDD

Antigène: PIDD (P53-Induced Death Domain Protein (PIDD))

Autre désignation: LRDD

Sujet: The protein encoded by this gene contains a leucine-rich repeat and a death domain. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.
Alias Symbols: DKFZp434D229, MGC16925, PIDD, LRDD
Protein Interaction Partner: CRADD, CRYAB, MDFI, SOX8, KEAP1, TEAD3, MAFG, AFP, RPAP3, FANCI, SENP3, TRIM32, ANP32B, HAX1, TELO2, NUP93, AIFM1, RFC5, RFC4, PRKDC, PPP6C, POLR2B, POLD1, PCNA, PRDX1, MCM7, ERCC5, ERCC2, DDB1, CASP2, FADD, RIPK1, IKBKG, CCDC85B, EFEMP2, MADD,
Protein Size: 753

Poids moléculaire: 83 kDa

ID gène: 55367

NCBI Accession: NM_018494, NP_060964

Pathways: Signalisation p53, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity