RPRD1B anticorps (C-Term)
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- Antigène Voir toutes RPRD1B Anticorps
- RPRD1B (Regulation of Nuclear Pre-mRNA Domain Containing 1B (RPRD1B))
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Épitope
- C-Term
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Reactivité
- Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval, Lapin, Cobaye
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp RPRD1B est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- QERSVYGGEF IQQLKLSMED SKSPPPKAAE EKKSLKRTFQ QIQEEEDDDY
- Homologie
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%
- Attributs du produit
- This is a rabbit polyclonal antibody against Rprd1b. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the C-terminal region of Mouse Rprd1b
- Top Product
- Discover our top product RPRD1B Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeat freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- RPRD1B (Regulation of Nuclear Pre-mRNA Domain Containing 1B (RPRD1B))
- Autre désignation
- Rprd1b (RPRD1B Produits)
- Synonymes
- anticorps fb23h08, anticorps zgc:55687, anticorps wu:fb23h08, anticorps rprd1ba, anticorps MGC130705, anticorps C13H20ORF77, anticorps C20orf77, anticorps CREPT, anticorps NET60, anticorps dJ1057B20.2, anticorps 2610304G08Rik, anticorps 2810446G03Rik, anticorps Crept, anticorps RGD1304782, anticorps regulation of nuclear pre-mRNA domain containing 1B, anticorps regulation of nuclear pre-mRNA domain containing 1B L homeolog, anticorps rprd1b, anticorps rprd1b.L, anticorps RPRD1B, anticorps Rprd1b
- Sujet
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Rprd1b interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. It is a transcriptional regulator which enhances expression of CCND1. It promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. It prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. It also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Rprd1b promotes cell proliferation.
Alias Symbols: 2610304G08Rik, 2810446G03Rik, Crept
Protein Size: 224 - Poids moléculaire
- 24 kDa
- ID gène
- 70470
- NCBI Accession
- NM_027434, NP_081710
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