Glutaredoxin 2 anticorps (Middle Region)

N° du produit ABIN2787395

Détail du produit anti-Glutaredoxin 2 anticorps

Antigène: Glutaredoxin 2 (GRX2)

Épitope: Middle Region

Reactivité: Humain, Rat, Souris, Cobaye, Cheval, Lapin, Boeuf (Vache), Chien, Mouton

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Glutaredoxin 2 est non-conjugé

Application: Western Blotting (WB)

Séquence: NVNYKVVELD LLEYGNQFQD ALYKMTGERT VPRIFVNGTF IGGATDTHRL H

Homologie: Cow: 86%, Dog: 86%, Guinea Pig: 86%, Horse: 86%, Human: 100%, Mouse: 93%, Rabbit: 86%, Rat: 86%, Sheep: 86%

Attributs du produit: This is a rabbit polyclonal antibody against GLRX2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human GLRX2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 164 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur Glutaredoxin 2

Antigène: Glutaredoxin 2 (GRX2)

Autre désignation: GLRX2 (GRX2 Produits)

Synonymes: anticorps ECK1049, anticorps JW1051, anticorps CGI-133, anticorps GRX2, anticorps 1700010P22Rik, anticorps AI645710, anticorps Grx2, anticorps glutaredoxin 2 (Grx2), anticorps glutaredoxin Grx2, anticorps thioredoxin, anticorps glutaredoxin 2, anticorps glutaredoxin 2 (thioltransferase), anticorps grxB, anticorps grx2, anticorps AF_RS10790, anticorps GLRX2, anticorps Glrx2

Sujet: GLRX2 is a glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress.GLRX2 is involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress.GLRX2 acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides.GLRX2 can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions.GLRX2 efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression of GLRX2 decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.
Alias Symbols: GRX2, bA101E13.1, CGI-133
Protein Interaction Partner: BAG3, TXNRD1,
Protein Size: 164

Poids moléculaire: 18 kDa

ID gène: 51022

NCBI Accession: NM_197962, NP_932066

UniProt: Q9NS18

Pathways: Cell RedoxHomeostasis