Glutaredoxin 2 anticorps (Middle Region)

N° du produit ABIN2787395

Cet anticorps anti-Glutaredoxin 2 Polyclonal Lapin (ABIN2787395) détecte spécifiquement Glutaredoxin 2 dans WB. L’anticorps est réactif avec des échantillons de Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin et Mouton.

Aperçu rapide pour Glutaredoxin 2 anticorps (Middle Region) (ABIN2787395)

Antigène: Glutaredoxin 2 (GRX2)

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin, Mouton

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Glutaredoxin 2 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Glutaredoxin 2 anticorps

Épitope: Middle Region

Fonction: GLRX2 Antibody - middle region

Séquence: NVNYKVVELD LLEYGNQFQD ALYKMTGERT VPRIFVNGTF IGGATDTHRL H

Homologie: Cow: 86%, Dog: 86%, Guinea Pig: 86%, Horse: 86%, Human: 100%, Mouse: 93%, Rabbit: 86%, Rat: 86%, Sheep: 86%

Attributs du produit: This is a rabbit polyclonal antibody against GLRX2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human GLRX2

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP57792-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur Glutaredoxin 2

Antigène: Glutaredoxin 2 (GRX2)

Autre désignation: GLRX2

Sujet:

Background Information: GLRX2 is a glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress.GLRX2 is involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress.GLRX2 acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides.GLRX2 can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions.GLRX2 efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression of GLRX2 decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.

Gene Name: Glutaredoxin 2

Alternative Symbols: GRX2, CGI-133

Protein Name: Glutaredoxin-2, mitochondrial

Poids moléculaire: 18kDa

ID gène: 51022

NCBI Accession: NP_932066

UniProt: Q9NS18

Pathways: Cell RedoxHomeostasis