Retinoblastoma 1 anticorps (N-Term)

N° du produit ABIN2787534

Cet anticorps anti-Retinoblastoma 1 est un anticorps Lapin Polyclonal détectant Retinoblastoma 1 dans WB. Adapté pour Humain, Souris, Rat, Boeuf (Vache), Lapin et Porc.

Aperçu rapide pour Retinoblastoma 1 anticorps (N-Term) (ABIN2787534)

Antigène: Retinoblastoma 1 (RB1)

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Lapin, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Retinoblastoma 1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Retinoblastoma 1 anticorps

Épitope: N-Term

Séquence: MPPKTPRKTA ATAAAAAAEP PAPPPPPPPE EDPEQDSGPE DLPLVRLEFE

Homologie: Cow: 93%, Human: 100%, Mouse: 80%, Pig: 93%, Rabbit: 93%, Rat: 79%

Attributs du produit: This is a rabbit polyclonal antibody against RB1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human RB1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 928 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur Retinoblastoma 1

Antigène: Retinoblastoma 1 (RB1)

Autre désignation: RB1

Sujet: The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.
Alias Symbols: OSRC, RB, pRb, pp110, p105-Rb
Protein Interaction Partner: RAF1, E2F1, ABL1, HDAC1, KDM2A, SMARCA4, USP7, UBC, DYRK1A, NEFM, DYRK1B, MAGEA11, ENC1, PPP1CA, CDKN1C, CDKN1A, CDK6, CDK4, CDK2, CCNE1, CCNA2, CCND1, HDAC11, PAX5, HIF1A, E2F4, CEBPE, CCNA1, SUMO1, UBE2I, TFAP2A, CDK3, CDK1, CCNC, CCNB1, MRPS18B, SUMO2,
Protein Size: 928

Poids moléculaire: 106 kDa

ID gène: 5925

NCBI Accession: NM_000321, NP_000312

UniProt: P06400

Pathways: Cycle Cellulaire, Intracellular Steroid Hormone Receptor Signaling Pathway, Mitotic G1-G1/S Phases, DNA Replication, Maintenance of Protein Location, Synthesis of DNA, Autophagy