ACTN1 anticorps (N-Term)

N° du produit ABIN2787669

Cet anticorps anti-ACTN1 Polyclonal Lapin (ABIN2787669) détecte spécifiquement ACTN1 dans WB et IHC. L’anticorps est réactif avec des échantillons de Humain, Souris, Rat, Boeuf (Vache), Lapin, Chien, Cobaye, Poisson zèbre (Danio rerio) et Cheval.

Aperçu rapide pour ACTN1 anticorps (N-Term) (ABIN2787669)

Antigène: ACTN1 (Actinin, alpha 1 (ACTN1))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Lapin, Chien, Cobaye, Poisson zèbre (Danio rerio), Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ACTN1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-ACTN1 anticorps

Épitope: N-Term

Séquence: DHYDSQQTND YMQPEEDWDR DLLLDPAWEK QQRKTFTAWC NSHLRKAGTQ

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 75%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 85%

Attributs du produit: This is a rabbit polyclonal antibody against ACTN1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human ACTN1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 892 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur ACTN1

Antigène: ACTN1 (Actinin, alpha 1 (ACTN1))

Autre désignation: ACTN1

Sujet: Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: FLJ40884
Protein Interaction Partner: SPERT, KCTD6, MICALL2, MYOZ2, EPM2AIP1, OAS1, ACTN3, ACTN1, SUMO2, SUMO3, HSF5, UBC, MDM2, EZH2, BMI1, ACTN4, CDAN1, DCAF8, SF3A3, STAM2, SRP19, UBD, IGSF8, ICAM1, CD81, ERBB2IP, SVIL, PDHX, RPS27, PSMA1, KPNA2, HCVgp1, PIAS4, GIT2, NUMBL, HSP90AB1, HSP90
Protein Size: 892

Poids moléculaire: 103 kDa

ID gène: 87

NCBI Accession: NM_001102, NP_001093

UniProt: P12814

Pathways: Cell-Cell Junction Organization