SHB anticorps (N-Term)

N° du produit ABIN2787818

Détail du produit anti-SHB anticorps

Antigène: SHB (Src Homology 2 Domain Containing Adaptor Protein B (SHB))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Lapin, Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SHB est non-conjugé

Application: Western Blotting (WB)

Séquence: ERPSQPPQAV PQASSAASAS CGPATASCFS ASSGSLPDDS GSTSDLIRAY

Homologie: Cow: 100%, Dog: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against SHB. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human SHB

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 509 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur SHB

Antigène: SHB (Src Homology 2 Domain Containing Adaptor Protein B (SHB))

Autre désignation: SHB (SHB Produits)

Synonymes: anticorps SHB, anticorps RP11-3J10.8, anticorps bA3J10.2, anticorps RGD1565350, anticorps BC028832, anticorps SH2 domain containing adaptor protein B, anticorps src homology 2 domain-containing transforming protein B, anticorps SHB, anticorps Shb

Sujet: SHB is the adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. SHB may play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. SHB may also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. SHB may also regulate IRS1 and IRS2 signaling in insulin-producing cells.
Alias Symbols: RP11-3J10.8, bA3J10.2
Protein Interaction Partner: SLC39A1, GRAP2, LAT, LCP2, EPS8, JAK3, IL2RG, KDR, SRC, ZAP70, PDGFRA, PLCG1, PIK3R1, VAV1, CRK, JAK1, IL2RB, GRB2, FGFR1, PDGFRB,
Protein Size: 509

Poids moléculaire: 55 kDa

ID gène: 6461

NCBI Accession: NM_003028, NP_003019

UniProt: Q15464