Rubicon anticorps (Middle Region)

N° du produit ABIN2787888

Cet anticorps Lapin Polyclonal détecte spécifiquement Rubicon dans WB. Il présente une réactivité avec des échantillons de Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye et Lapin.

Aperçu rapide pour Rubicon anticorps (Middle Region) (ABIN2787888)

Antigène: Rubicon (KIAA0226) (KIAA0226)

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Rubicon est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Rubicon anticorps

Épitope: Middle Region

Fonction: RUBCN Antibody - middle region

Séquence: DQEGGGESQL SSVLRRSSFS EGQTLTVTSG AKKSHIRSHS DTSIASRGAP

Homologie: Cow: 85%, Dog: 85%, Guinea Pig: 92%, Human: 100%, Mouse: 92%, Rabbit: 85%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against KIAA0226. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human KIAA0226

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP58950-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur Rubicon

Antigène: Rubicon (KIAA0226) (KIAA0226)

Autre désignation: RUBCN

Sujet:

Background Information: The protein encoded by this gene is a negative regulator of autophagy and endocytic trafficking and controls endosome maturation. This protein contains two conserved domains, an N-terminal RUN domain and a C-terminal DUF4206 domain. The RUN domain is involved in Ras-like GTPase signaling, and the DUF4206 domain contains a diacylglycerol (DAG) binding-like motif. Mutation in this gene results in deletion of the DAG binding-like motif and causes a recessive ataxia. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Gene Name: RUN and cysteine rich domain containing beclin 1 interacting protein

Alternative Symbols: SCAR15, RUBICON, KIAA0226

Protein Name: run domain Beclin-1-interacting and cysteine-rich domain-containing protein

Poids moléculaire: 103kDa

ID gène: 9711

NCBI Accession: NP_001139114

UniProt: Q92622

Pathways: Autophagy