CASP5 anticorps (Middle Region)

N° du produit ABIN2787906

Détail du produit anti-CASP5 anticorps

Antigène: CASP5 (Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5))

Épitope: Middle Region

Reactivité: Humain, Boeuf (Vache), Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CASP5 est non-conjugé

Application: Western Blotting (WB)

Séquence: VIIVQACRGE KHGELWVRDS PASLALISSQ SSENLEADSV CKIHEEKDFI

Homologie: Cow: 83%, Guinea Pig: 82%, Human: 100%

Attributs du produit: This is a rabbit polyclonal antibody against CASP5. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human CASP5

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 376 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur CASP5

Antigène: CASP5 (Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5))

Autre désignation: CASP5 (CASP5 Produits)

Synonymes: anticorps ICE(rel)III, anticorps ICEREL-III, anticorps ICH-3, anticorps CASP5, anticorps caspase 5, anticorps caspase-5, anticorps CASP5, anticorps LOC100437308

Sujet: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein, this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene.
Alias Symbols: ICE(rel)III, ICEREL-III, ICH-3, MGC141966
Protein Interaction Partner: PPHLN1, NLRP1, CASP5, MAX,
Protein Size: 376

Poids moléculaire: 43 kDa

ID gène: 838

NCBI Accession: NM_001136109, NP_001129581

UniProt: P51878

Pathways: Inflammasome