IL7R anticorps (Middle Region)

N° du produit ABIN2787929

L’anticorps anti-IL7R Polyclonal Lapin est utilisé pour la détection de IL7R dans des échantillons de Humain, Cheval et Chien. Il a été validé pour WB.

Aperçu rapide pour IL7R anticorps (Middle Region) (ABIN2787929)

Antigène: IL7R (Interleukin 7 Receptor (IL7R))

Reactivité: Humain, Cheval, Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IL7R est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-IL7R anticorps

Épitope: Middle Region

Fonction: IL7R Antibody - middle region

Séquence: ESFLDCQIHR VDDIQARDEV EGFLQDTFPQ QLEESEKQRL GGDVQSPNCP

Homologie: Dog: 92%, Horse: 83%, Human: 100%

Attributs du produit: This is a rabbit polyclonal antibody against IL7R. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human IL7R

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP59084-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur IL7R

Antigène: IL7R (Interleukin 7 Receptor (IL7R))

Autre désignation: IL7R

Sujet:

Targeted Subunit: alpha

Background Information: The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID).

Gene Name: Interleukin 7 receptor

Alternative Symbols: ILRA, CD127, IL7RA, CDW127, IL-7R-alpha

Protein Name: Interleukin-7 receptor subunit alpha

Poids moléculaire: 49kDa

ID gène: 3575

NCBI Accession: NP_002176

UniProt: P16871

Pathways: Signalistation JAK/STAT, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Regulation of Cell Size