IL7R anticorps (Middle Region)
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- Antigène Voir toutes IL7R Anticorps
- IL7R (Interleukin 7 Receptor (IL7R))
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Épitope
- Middle Region
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Reactivité
- Humain, Cheval, Chien
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp IL7R est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- ESFLDCQIHR VDDIQARDEV EGFLQDTFPQ QLEESEKQRL GGDVQSPNCP
- Homologie
- Dog: 92%, Horse: 83%, Human: 100%
- Attributs du produit
- This is a rabbit polyclonal antibody against IL7R. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the middle region of human IL7R
- Top Product
- Discover our top product IL7R Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 459 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- IL7R (Interleukin 7 Receptor (IL7R))
- Autre désignation
- IL7R (IL7R Produits)
- Synonymes
- anticorps IL7R, anticorps CD127, anticorps IL-7Ralpha, anticorps CDW127, anticorps IL-7R-alpha, anticorps IL7RA, anticorps ILRA, anticorps IL-7RA, anticorps interleukin 7 receptor, anticorps IL7R, anticorps Il7r
- Sujet
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The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID).
Alias Symbols: CD127, CDW127, IL-7R-alpha, IL7RA, ILRA
Protein Interaction Partner: KIT, JAK3, SNRPG, SNRPD3, SNRPD2, SNRPD1, SNRPB, SNRPA, SNRNP70, SRSF3, SAFB, RPS20, RPS3, RPL31, RPL29, RPL30, RPL22, RPL18, RPL15, RPL8, RPL7, RPL6, RBM3, PURB, PURA, PTMA, PTBP1, EIF2AK2, YBX1, NONO, NCL, MAP4, RPSA, ILF3, ILF2, HNRNPU, HNRNPL, HNRNPH3
Protein Size: 459 - Poids moléculaire
- 49 kDa
- ID gène
- 3575
- NCBI Accession
- NM_002185, NP_002176
- UniProt
- P16871
- Pathways
- Signalistation JAK/STAT, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Regulation of Cell Size
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