USP8 anticorps (C-Term)

N° du produit ABIN2788008

Cet anticorps anti-USP8 Polyclonal Lapin (ABIN2788008) détecte spécifiquement USP8 dans WB et IHC. L’anticorps est réactif avec des échantillons de Humain, Souris, Porc, Rat, Boeuf (Vache), Chien, Cheval, Cobaye, Lapin et Poisson zèbre (Danio rerio).

Aperçu rapide pour USP8 anticorps (C-Term) (ABIN2788008)

Antigène: USP8 (Ubiquitin Specific Peptidase 8 (USP8))

Reactivité: Humain, Souris, Porc, Rat, Boeuf (Vache), Chien, Cheval, Cobaye, Lapin, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp USP8 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-USP8 anticorps

Épitope: C-Term

Fonction: USP8 Antibody - C-terminal region

Séquence: FAGYSQQDSQ ELLLFLMDGL HEDLNKADNR KRYKEENNDH LDDFKAAEHA

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 93%, Rat: 93%, Zebrafish: 79%

Attributs du produit: This is a rabbit polyclonal antibody against USP8. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human USP8

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP59291-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur USP8

Antigène: USP8 (Ubiquitin Specific Peptidase 8 (USP8))

Autre désignation: USP8

Sujet:

Background Information: USP8 is a hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. USP8 converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. USP8 catalytic activity is enhanced in the M phase. USP8 is involved in cell proliferation. USP8 is required to enter into S phase in response to serum stimulation. USP8 may regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. USP8 probably regulates the stability of STAM2 and RASGRF1. USP8 regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle.USP8 deubiquitinates EPS15 and controles tyrosine kinase stability.USP8 removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. USP8 is involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules.

Gene Name: Ubiquitin specific peptidase 8

Alternative Symbols: UBPY, PITA4, SPG59, HumORF8

Protein Name: Ubiquitin carboxyl-terminal hydrolase 8

Poids moléculaire: 127kDa

ID gène: 9101

NCBI Accession: NP_005145

UniProt: P40818