USP8 anticorps (N-Term)

N° du produit ABIN2788009

Détail du produit anti-USP8 anticorps

Antigène: USP8 (Ubiquitin Specific Peptidase 8 (USP8))

Épitope: N-Term

Reactivité: Humain, Rat, Porc, Boeuf (Vache), Chien, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp USP8 est non-conjugé

Application: Western Blotting (WB)

Séquence: KGSLENVLDS KDKTQKSNGE KNEKCETKEK GAITAKELYT MMTDKNISLI

Homologie: Cow: 85%, Dog: 85%, Horse: 92%, Human: 100%, Pig: 85%, Rat: 77%

Attributs du produit: This is a rabbit polyclonal antibody against USP8. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human USP8

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 1118 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur USP8

Antigène: USP8 (Ubiquitin Specific Peptidase 8 (USP8))

Autre désignation: USP8 (USP8 Produits)

Synonymes: anticorps HumORF8, anticorps UBPY, anticorps AI574262, anticorps AW557536, anticorps Ubpy, anticorps mKIAA0055, anticorps ubiquitin carboxyl-terminal hydrolase 8, anticorps ubiquitin specific peptidase 8, anticorps LOC9310109, anticorps MGYG_00369, anticorps USP8, anticorps Usp8

Sujet: USP8 is a hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. USP8 converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. USP8 catalytic activity is enhanced in the M phase. USP8 is involved in cell proliferation. USP8 is required to enter into S phase in response to serum stimulation. USP8 may regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. USP8 probably regulates the stability of STAM2 and RASGRF1. USP8 regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle.USP8 deubiquitinates EPS15 and controles tyrosine kinase stability.USP8 removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. USP8 is involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules.
Alias Symbols: FLJ34456, HumORF8, KIAA0055, MGC129718, UBPY
Protein Interaction Partner: VAMP8, LRIG1, TARDBP, UBC, PTEN, STAT6, TSEN2, POLD3, HTT, YWHAB, YWHAQ, YWHAE, EGFR, PTPN23, SRC, ERBB4, UBE2I, UBE2G1, FARSB, VPS4B, TRIM63, TRIM55, PJA1, USP28, TRIM54, USP21, USP15, GRAP2, CHMP4C, CHMP1B, CHMP2A, CHMP2B, RNF41, USP8, SPP1, CHMP1A, NBR
Protein Size: 1118

Poids moléculaire: 127 kDa

ID gène: 9101

NCBI Accession: NM_005154, NP_005145

UniProt: P40818