UCHL3 anticorps (Middle Region)

N° du produit ABIN2788014

Cet anticorps Lapin Polyclonal détecte spécifiquement UCHL3 dans WB. Il présente une réactivité avec des échantillons de Humain, Rat, Souris, Boeuf (Vache), Cheval, Chien, Lapin, Cobaye et Saccharomyces cerevisiae.

Aperçu rapide pour UCHL3 anticorps (Middle Region) (ABIN2788014)

Antigène: UCHL3 (Uchl3) (Ubiquitin Carboxyl-terminal Esterase L3 (Ubiquitin Thiolesterase) (Uchl3))

Reactivité: Humain, Rat, Souris, Boeuf (Vache), Cheval, Chien, Lapin, Cobaye, Saccharomyces cerevisiae

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp UCHL3 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-UCHL3 anticorps

Épitope: Middle Region

Fonction: Uchl3 Antibody - middle region

Séquence: IHAIANNKDK MHFESGSTLK KFLEESVSMS PEERAKFLEN YDAIRVTHET

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 83%

Attributs du produit: This is a rabbit polyclonal antibody against Uchl3. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of Mouse Uchl3

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP59298-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur UCHL3

Antigène: UCHL3 (Uchl3) (Ubiquitin Carboxyl-terminal Esterase L3 (Ubiquitin Thiolesterase) (Uchl3))

Autre désignation: Uchl3

Sujet:

Background Information: Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Uchl3 has a 10-fold preference for Arg and Lys at position P3", and exhibits a preference towards 'Lys-48'-linked Ubiquitin chains. Uchl3 deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Uchl3 indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. It is required for stress-response retinal, skeletal muscle and germ cell maintenance. Uchl3 may be involved in working memory and can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome.

Gene Name: ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)

Alternative Symbols: -

Protein Name: Ubiquitin carboxyl-terminal hydrolase isozyme L3

Poids moléculaire: 26kDa

ID gène: 50933

NCBI Accession: NP_057932

UniProt: Q9JKB1

Pathways: Feeding Behaviour, Positive Regulation of fat Cell Differentiation