USP20 anticorps (Middle Region)

N° du produit ABIN2788022

L’anticorps Lapin Polyclonal anti-USP20 a été validé pour WB. Il convient pour détecter USP20 dans des échantillons de Humain, Souris, Rat, Chien, Lapin, Cheval, Boeuf (Vache) et Cobaye.

Aperçu rapide pour USP20 anticorps (Middle Region) (ABIN2788022)

Antigène: USP20 (Ubiquitin Specific Peptidase 20 (USP20))

Reactivité: Humain, Souris, Rat, Chien, Lapin, Cheval, Boeuf (Vache), Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp USP20 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-USP20 anticorps

Épitope: Middle Region

Séquence: PAEAQPPSPR SSSPCRTPEP DNDAHLRSSS RPCSPVHHHE GHAKLSSSPP

Homologie: Cow: 92%, Dog: 92%, Guinea Pig: 100%, Horse: 92%, Human: 100%, Mouse: 85%, Rabbit: 100%, Rat: 92%

Attributs du produit: This is a rabbit polyclonal antibody against USP20. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human USP20

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 913 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur USP20

Antigène: USP20 (Ubiquitin Specific Peptidase 20 (USP20))

Autre désignation: USP20

Sujet: USP20 is a deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling.USP20 acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). USP20 plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. USP20 deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity.USP20 mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Alias Symbols: KIAA1003, LSFR3A, VDU2
Protein Interaction Partner: MDFI, MAGEA11, TRIM23, ALAS1, FATE1, BEND5, SPRY2, VAPB, CCDC36, BEND7, RAD17, NEURL4, USP33, USP20, CCP110, ADRB2, PJA1, USP28, USP21, USP15, PLA2G2A, UBC, VHL, HIF1A, VAPA, HERC2P2, PLEKHA7, SYTL4, GPT2, POLDIP3, RGPD5, ATAD3B, MAP7D1, LRRC59, ZNF770, S
Protein Size: 913

Poids moléculaire: 102 kDa

ID gène: 10868

NCBI Accession: NM_006676, NP_006667

UniProt: Q9Y2K6

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling