COPS6 anticorps (Middle Region)

N° du produit ABIN2788037

Détail du produit anti-COPS6 anticorps

Antigène: COPS6 (COP9 Signalosome Complex Subunit 6 (COPS6))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp COPS6 est non-conjugé

Application: Western Blotting (WB)

Séquence: DHVARMTATG SGENSTVAEH LIAQHSAIKM LHSRVKLILE YVKASEAGEV

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Attributs du produit: This is a rabbit polyclonal antibody against COPS6. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human COPS6

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 327 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-COPS6 (ABIN2788037)

Pick, Golan, Zimbler, Guo, Sharaby, Tsuge, Hofmann, Wei: "The minimal deneddylase core of the COP9 signalosome excludes the Csn6 MPN- domain." dans: PLoS ONE, Vol. 7, Issue 8, pp. e43980, (2012) (PubMed).

Détails sur COPS6

Antigène: COPS6 (COP9 Signalosome Complex Subunit 6 (COPS6))

Autre désignation: COPS6 (COPS6 Produits)

Synonymes: anticorps CG6932, anticorps CH6, anticorps Csn6, anticorps Dch6, anticorps Dmel\\CG6932, anticorps zgc:112075, anticorps Sgn3, anticorps VIP/MOV34, anticorps CSN6, anticorps MOV34-34KD, anticorps COP9 signalosome subunit 6, anticorps COP-9 SigNalosome subunit, anticorps COPS6, anticorps Cops6, anticorps CSN6, anticorps cops6, anticorps csn-6

Sujet: The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr.
Alias Symbols: CSN6, MOV34-34KD
Protein Interaction Partner: NEDD8, CUL1, UBC, COPS5, GPS1, SUMO1, POP7, COPS7B, COPS7A, CUL4B, USP7, COPS4, FBXO6, FBXW4, IGHV3OR15-7, vpr, TP63, RFWD2, SFN, IRF5, COPS8, COPS2, COPS3, DDB2, DDB1, ERCC8, TOR1AIP2, LRR1, RBX1, VPRBP, LRRC14, CUL2, CUL3, CUL4A, CUL5, TCEB2, TCEB1, SKP
Protein Size: 327

Poids moléculaire: 36 kDa

ID gène: 10980

NCBI Accession: NM_006833, NP_006824

UniProt: Q7L5N1

Pathways: Cycle Cellulaire