Members of the F-box protein family, such as FBXL12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1, MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).
Alias Symbols: FLJ20188, Fbl12
Protein Interaction Partner: LNX1, DOCK8, PRAME, STYX, HSP90AA1, CUL1, SKP1, RNF32, ECSIT, MAST1, CDC37, PSEN2, PSEN1, APOE, A2M, UBC, COPS6, RBX1, CDKN1C, JUN, FXYD3, SMAD1, TGFBR1,
Protein Size: 326