GCH1 anticorps (N-Term)

N° du produit ABIN2788139

L’anticorps anti-GCH1 Polyclonal Lapin est utilisé pour la détection de GCH1 dans des échantillons de Humain, Rat, Boeuf (Vache), Chien et Lapin. Il a été validé pour WB.

Aperçu rapide pour GCH1 anticorps (N-Term) (ABIN2788139)

Antigène: GCH1 (GTP Cyclohydrolase 1 (GCH1))

Reactivité: Humain, Rat, Boeuf (Vache), Chien, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GCH1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-GCH1 anticorps

Épitope: N-Term

Fonction: GCH1 Antibody - N-terminal region

Séquence: PPRPEAKSAQ PADGWKGERP RSEEDNELNL PNLAAAYSSI LSSLGENPQR

Homologie: Cow: 100%, Dog: 100%, Human: 100%, Rabbit: 100%, Rat: 86%

Attributs du produit: This is a rabbit polyclonal antibody against GCH1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N-terminal region of Human GCH1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP59619-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur GCH1

Antigène: GCH1 (GTP Cyclohydrolase 1 (GCH1))

Autre désignation: GCH1

Sujet:

Background Information: This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described, however, not all variants give rise to a functional enzyme.

Gene Name: GTP cyclohydrolase 1

Alternative Symbols: GCH, DYT5, DYT14, DYT5a, GTPCH1, HPABH4B, GTP-CH-1

Protein Name: GTP cyclohydrolase 1

Poids moléculaire: 27kDa

ID gène: 2643

UniProt: P30793