BTBD12 anticorps (N-Term)

N° du produit ABIN2788239

Cet anticorps anti-BTBD12 est un anticorps Lapin Polyclonal détectant BTBD12 dans WB. Adapté pour Humain et Lapin.

Aperçu rapide pour BTBD12 anticorps (N-Term) (ABIN2788239)

Antigène: BTBD12 (BTB (POZ) Domain Containing 12 (BTBD12))

Reactivité: Humain, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BTBD12 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-BTBD12 anticorps

Épitope: N-Term

Séquence: TKTLQGPAEK KPPSGSQAPR TKKQRVTKWQ ASEPAHSVNG EGGVLASAPD

Homologie: Human: 100%, Rabbit: 91%

Attributs du produit: This is a rabbit polyclonal antibody against BTBD12. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human BTBD12

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 1834 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur BTBD12

Antigène: BTBD12 (BTB (POZ) Domain Containing 12 (BTBD12))

Autre désignation: BTBD12

Sujet: This gene encodes a structure-specific endonuclease subunit. The encoded protein contains a central BTB domain and it forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases, and also associates with MSH2/MSH3 mismatch repair complex, telomere binding complex TERF2(TRF2)-TERF2IP(RAP1), the protein kinase PLK1 and the uncharacterized protein C20orf94. The multiprotein complex is required for repair of specific types of DNA lesions and is critical for cellular responses to replication fork failure. The encoded protein acts as a docking platform for the assembly of multiple structure-specific endonucleases.
Alias Symbols: KIAA1784, KIAA1987, MUS312, SLX4, FANCP, BTBD12
Protein Interaction Partner: MUS81, vpr, SLX1A, SLX1B, DCLRE1B, TERF2, ERCC4, UBC, ERCC1, APP, EME1, PCNA, MSH2, MSH6, DDB1, SLX4IP, SPRTN, TERF2IP, VCP, PLK1, SUMO2, PGAM5, DCAF10, LRRC1, GID8, TEX10, GLTSCR2, NUP188, NUP50, PNMA2, TSPYL1, PSMB4, MSH3, KPNA1,
Protein Size: 1834

Poids moléculaire: 200 kDa

ID gène: 84464

NCBI Accession: NM_032444, NP_115820

UniProt: Q8IY92

Pathways: Réparation de l'ADN