CD22 anticorps (N-Term)

N° du produit ABIN2788241

Cet anticorps Lapin Polyclonal détecte spécifiquement CD22 dans WB. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour CD22 anticorps (N-Term) (ABIN2788241)

Antigène: CD22 (CD22 Molecule (CD22))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CD22 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-CD22 anticorps

Épitope: N-Term

Fonction: CD22 Antibody - N-terminal region

Séquence: TYRALDGDLE SFILFHNPEY NKNTSKFDGT RLYESTKDGK VPSEQKRVQF

Homologie: Human: 100%

Attributs du produit: This is a rabbit polyclonal antibody against CD22. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human CD22

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP59863-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur CD22

Antigène: CD22 (CD22 Molecule (CD22))

Autre désignation: CD22

Sujet:

Background Information: CD22 mediates B-cell B-cell interactions. CD22 may be involved in the localization of B-cells in lymphoid tissues. CD22 binds sialylated glycoproteins, one of which is CD45. CD22 preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response CD22 seems to be involved in regulation of B-cell antigen receptor signaling. CD22 plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

Gene Name: CD22 Molecule

Alternative Symbols: SIGLEC2, SIGLEC-2

Protein Name: B-cell receptor CD22

Poids moléculaire: 95kDa

ID gène: 933

NCBI Accession: NP_001762

UniProt: P20273