DDB2 anticorps (C-Term)

N° du produit ABIN2788357

Cet anticorps Lapin Polyclonal détecte spécifiquement DDB2 dans WB. Il présente une réactivité avec des échantillons de Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval et Lapin.

Aperçu rapide pour DDB2 anticorps (C-Term) (ABIN2788357)

Antigène: DDB2 (Damage-Specific DNA Binding Protein 2, 48kDa (DDB2))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DDB2 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-DDB2 anticorps

Épitope: C-Term

Fonction: DDB2 Antibody - C-terminal region

Séquence: IVVGRYPDPN FKSCTPYELR TIDVFDGNSG KMMCQLYDPE SSGISSLNEF

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 79%, Rabbit: 93%, Rat: 86%

Attributs du produit: This is a rabbit polyclonal antibody against DDB2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human DDB2

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP60163-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur DDB2

Antigène: DDB2 (Damage-Specific DNA Binding Protein 2, 48kDa (DDB2))

Autre désignation: DDB2

Sujet:

Background Information: This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities.

Gene Name: Damage-specific DNA binding protein 2, 48 kDa

Alternative Symbols: XPE, DDBB, UV-DDB2

Protein Name: DNA damage-binding protein 2

Poids moléculaire: 48kDa

ID gène: 1643

NCBI Accession: NP_000098

UniProt: Q92466

Pathways: Réparation de l'ADN