EXOSC9 anticorps (N-Term)

N° du produit ABIN2789034

Détail du produit anti-EXOSC9 anticorps

Antigène: EXOSC9 (Exosome Component 9 (EXOSC9))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval, Porc, Lapin, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EXOSC9 est non-conjugé

Application: Western Blotting (WB)

Séquence: ERRFLLRAIE EKKRLDGRQT YDYRNIRISF GTDYGCCIVE LGKTRVLGQV

Homologie: Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against EXOSC9. It was validated on Western Blot.

Purification: Affinity Purified

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 355 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur EXOSC9

Antigène: EXOSC9 (Exosome Component 9 (EXOSC9))

Autre désignation: EXOSC9 (EXOSC9 Produits)

Sujet: EXOSC9 is a non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC9 binds to ARE-containing RNAs.
Alias Symbols: PM/Scl-75, PMSCL1, RRP45, Rrp45p, p5, p6
Protein Interaction Partner: UBC, EXOSC4, MPG, AICDA, CSNK2A1, EXOSC5, EXOSC10, EXOSC3, EXOSC2, DIS3, DIS3L, CHMP4B, CAND1, COPS5, CUL3, SUMO2, UBE2I, EXOSC1, SKIV2L2, EXOSC6, DDX39A, MPP6, EXOSC7, EXOSC8, EXOSC9, DDX39B,
Protein Size: 355

Poids moléculaire: 39 kDa

ID gène: 5393

NCBI Accession: NM_005033, NP_005024

UniProt: Q06265