PDE5A anticorps (C-Term)

N° du produit ABIN2789423

Cité dans 1 publication. Cet anticorps anti-PDE5A Polyclonal Lapin (ABIN2789423) détecte spécifiquement PDE5A dans WB et IHC. L’anticorps est réactif avec des échantillons de Humain, Rat, Souris, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin et Poisson zèbre (Danio rerio).

Aperçu rapide pour PDE5A anticorps (C-Term) (ABIN2789423)

Antigène: PDE5A (phosphodiesterase 5A, cGMP-Specific (PDE5A))

Reactivité: Humain, Rat, Souris, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PDE5A est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-PDE5A anticorps

Épitope: C-Term

Fonction: PDE5A Antibody - C-terminal region

Séquence: TACDLSAITK PWPIQQRIAE LVATEFFDQG DRERKELNIE PTDLMNREKK

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Zebrafish: 82%

Attributs du produit: This is a rabbit polyclonal antibody against PDE5A. It was validated on Western Blot.

Purification: Affinity Purified

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP63250-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-PDE5A (ABIN2789423)

Ioki, Wu, Takayama, Motohashi, Wakai, Funahashi: "A phosphodiesterase type-5 inhibitor, sildenafil, induces sperm capacitation and penetration into porcine oocytes in a chemically defined medium." dans: Theriogenology, Vol. 85, Issue 3, pp. 428-33, (2016) (PubMed).

Détails sur PDE5A

Antigène: PDE5A (phosphodiesterase 5A, cGMP-Specific (PDE5A))

Autre désignation: PDE5A

Sujet:

Background Information: This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms.

Gene Name: Phosphodiesterase 5A, cGMP-specific

Alternative Symbols: CN5A, PDE5, CGB-PDE

Protein Name: cGMP-specific 3',5'-cyclic phosphodiesterase

Poids moléculaire: 93kDa

ID gène: 8654

NCBI Accession: NP_246273

UniProt: O76074

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling