Macrophage Scavenger Receptor 1 anticorps (N-Term)

N° du produit ABIN2789552

Cet anticorps anti-Macrophage Scavenger Receptor 1 Polyclonal Lapin (ABIN2789552) détecte spécifiquement Macrophage Scavenger Receptor 1 dans WB. L’anticorps est réactif avec des échantillons de Humain, Porc, Chien, Cheval et Boeuf (Vache).

Aperçu rapide pour Macrophage Scavenger Receptor 1 anticorps (N-Term) (ABIN2789552)

Antigène: Macrophage Scavenger Receptor 1 (MSR1)

Reactivité: Humain, Porc, Chien, Cheval, Boeuf (Vache)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Macrophage Scavenger Receptor 1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Macrophage Scavenger Receptor 1 anticorps

Épitope: N-Term

Fonction: MSR1 Antibody - N-terminal region

Séquence: VSSTNANDIT QSLTGKGNDS EEEMRFQEVF MEHMSNMEKR IQHILDMEAN

Homologie: Cow: 82%, Dog: 93%, Horse: 85%, Human: 100%, Pig: 82%

Attributs du produit: This is a rabbit polyclonal antibody against MSR1. It was validated on Western Blot.

Purification: Affinity Purified

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP63579-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur Macrophage Scavenger Receptor 1

Antigène: Macrophage Scavenger Receptor 1 (MSR1)

Autre désignation: MSR1

Sujet:

Background Information: This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.

Gene Name: Macrophage scavenger receptor 1

Alternative Symbols: SRA, SR-A, CD204, SR-AI, phSR1, phSR2, SCARA1, SR-AII, SR-AIII

Protein Name: Macrophage scavenger receptor types I and II

Poids moléculaire: 50kDa

ID gène: 4481

NCBI Accession: NP_619729

UniProt: P21757