Macrophage Scavenger Receptor 1 anticorps (N-Term)

N° du produit ABIN2789552

Détail du produit anti-Macrophage Scavenger Receptor 1 anticorps

Antigène: Macrophage Scavenger Receptor 1 (MSR1)

Épitope: N-Term

Reactivité: Humain, Porc, Chien, Boeuf (Vache), Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Macrophage Scavenger Receptor 1 est non-conjugé

Application: Western Blotting (WB)

Séquence: VSSTNANDIT QSLTGKGNDS EEEMRFQEVF MEHMSNMEKR IQHILDMEAN

Homologie: Cow: 82%, Dog: 93%, Horse: 85%, Human: 100%, Pig: 82%

Attributs du produit: This is a rabbit polyclonal antibody against MSR1. It was validated on Western Blot.

Purification: Affinity Purified

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 451 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur Macrophage Scavenger Receptor 1

Antigène: Macrophage Scavenger Receptor 1 (MSR1)

Autre désignation: MSR1 (MSR1 Produits)

Synonymes: anticorps CD204, anticorps SCARA1, anticorps SR-A, anticorps SRA, anticorps phSR1, anticorps phSR2, anticorps MRS-A, anticorps MSR, anticorps MSR-A, anticorps SR-AI, anticorps SR-AII, anticorps Scara1, anticorps Scvr, anticorps MSR1, anticorps RGD1564316, anticorps macrophage scavenger receptor 1, anticorps scavenger receptor class A member 5, anticorps MSR1, anticorps Msr1, anticorps SCARA5

Sujet: This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.
Alias Symbols: CD204, SCARA1, SR-A, phSR1, phSR2, SRA
Protein Interaction Partner: SEC22A, LEPROTL1, MALL, NKG7, ATP6V0C, IQCB1, TRAF6, HSPA1A,
Protein Size: 451

Poids moléculaire: 50 kDa

ID gène: 4481

NCBI Accession: NM_138715, NP_619729

UniProt: P21757