PDE6B anticorps (N-Term)

N° du produit ABIN2789554

L’anticorps anti-PDE6B Polyclonal Lapin est utilisé pour la détection de PDE6B dans des échantillons de Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval, Cobaye, Lapin et Poisson zèbre (Danio rerio). Il a été validé pour WB.

Aperçu rapide pour PDE6B anticorps (N-Term) (ABIN2789554)

Antigène: PDE6B (phosphodiesterase 6B, CGMP-Specific, Rod, beta (PDE6B))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval, Cobaye, Lapin, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PDE6B est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-PDE6B anticorps

Épitope: N-Term

Fonction: PDE6B Antibody - N-terminal region

Séquence: LSMPIVNKKE EIVGVATFYN RKDGKPFDEQ DEVLMESLTQ FLGWSVMNTD

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Attributs du produit: This is a rabbit polyclonal antibody against PDE6B. It was validated on Western Blot.

Purification: Affinity Purified

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP63581-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur PDE6B

Antigène: PDE6B (phosphodiesterase 6B, CGMP-Specific, Rod, beta (PDE6B))

Autre désignation: PDE6B

Sujet:

Targeted Subunit: beta

Background Information: Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Name: Phosphodiesterase 6B, cGMP-specific, rod, beta

Alternative Symbols: rd1, PDEB, RP40, CSNB3, CSNBAD2, GMP-PDEbeta

Protein Name: Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta

Poids moléculaire: 63kDa

ID gène: 5158

NCBI Accession: NP_001138764

UniProt: E7ETT3

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction