Transferrin Receptor anticorps (N-Term)

N° du produit ABIN2789600

Cet anticorps anti-Transferrin Receptor est un anticorps Lapin Polyclonal détectant Transferrin Receptor dans WB et IHC. Adapté pour Humain et Lapin.

Aperçu rapide pour Transferrin Receptor anticorps (N-Term) (ABIN2789600)

Antigène: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Reactivité: Humain, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Transferrin Receptor est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-Transferrin Receptor anticorps

Épitope: N-Term

Séquence: PVREEPGEDF PAARRLYWDD LKRKLSEKLD STDFTGTIKL LNENSYVPRE

Homologie: Human: 100%, Rabbit: 91%

Attributs du produit: This is a rabbit polyclonal antibody against TFRC. It was validated on Western Blot.

Purification: Affinity Purified

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 760 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur Transferrin Receptor

Antigène: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Autre désignation: TFRC

Sujet: TFRC is a cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system By similarity. A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.
Alias Symbols: CD71, TFR, TFR1, TRFR, T9, TR, p90
Protein Interaction Partner: HUWE1, UBC, SGTA, CAV1, TP53, RAB8A, RANBP9, LGR4, MDM2, RPA3, RPA2, RPA1, ASB4, RNF2, OPTN, ADRB2, CLN3, MARCH8, env, MARCH1, MYO1G, VCAM1, ITGA4, FN1, ATF2, B4GALT1, ESR1, ATP6V1B1, FBXO6, KCNA5, KCNA3, vpu, SH3BP4, PARK2, LAPTM4B, LAPTM4A, HGS, SUMO2,
Protein Size: 760

Poids moléculaire: 84 kDa

ID gène: 7037

NCBI Accession: NM_003234, NP_003225

UniProt: P02786

Pathways: Transition Metal Ion Homeostasis