HCAR2 anticorps (C-Term)

N° du produit ABIN2789654

Détail du produit anti-HCAR2 anticorps

Antigène: HCAR2 (Hydroxycarboxylic Acid Receptor 2 (HCAR2))

Épitope: C-Term

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Cobaye, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HCAR2 est non-conjugé

Application: Western Blotting (WB)

Séquence: YYFSSPSFPN FFSTLINRCL QRKMTGEPDN NRSTSVELTG DPNKTRGAPE

Homologie: Cow: 91%, Guinea Pig: 92%, Human: 100%, Mouse: 100%, Rabbit: 92%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against HCAR2. It was validated on Western Blot.

Purification: Affinity Purified

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 363 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur HCAR2

Antigène: HCAR2 (Hydroxycarboxylic Acid Receptor 2 (HCAR2))

Autre désignation: HCAR2 (HCAR2 Produits)

Synonymes: anticorps GPR109A, anticorps HCA2, anticorps HM74a, anticorps HM74b, anticorps NIACR1, anticorps PUMAG, anticorps Puma-g, anticorps Gpr109a, anticorps Gpr109b, anticorps HM74, anticorps Hcar2, anticorps PUMA-G, anticorps Pumag, anticorps mHM74b, anticorps HCAR2, anticorps HCAR3, anticorps hydroxycarboxylic acid receptor 2, anticorps HCAR2, anticorps Hcar2, anticorps LOC527744

Sujet: HCAR2 acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.
Alias Symbols: HM74a, HM74b, NIACR1, PUMAG, Puma-g
Protein Size: 363

Poids moléculaire: 42 kDa

ID gène: 338442

NCBI Accession: NM_177551, NP_808219

UniProt: Q8TDS4