DUSP4 anticorps (C-Term)

N° du produit ABIN2789728

Détail du produit anti-DUSP4 anticorps

Antigène: DUSP4 (Dual Specificity Phosphatase 4 (DUSP4))

Épitope: C-Term

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DUSP4 est non-conjugé

Application: Western Blotting (WB)

Séquence: GQLLQFESQV LATSCAAEAA SPSGPLRERG KTPATPTSQF VFSFPVSVGV

Homologie: Cow: 92%, Dog: 85%, Guinea Pig: 86%, Horse: 92%, Human: 100%, Mouse: 92%, Pig: 92%, Rabbit: 85%, Rat: 92%

Attributs du produit: This is a rabbit polyclonal antibody against DUSP4. It was validated on Western Blot.

Purification: Affinity Purified

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 394 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur DUSP4

Antigène: DUSP4 (Dual Specificity Phosphatase 4 (DUSP4))

Autre désignation: DUSP4 (DUSP4 Produits)

Synonymes: anticorps zgc:55423, anticorps DUSP4, anticorps typ, anticorps hvh2, anticorps mkp2, anticorps mkp-2, anticorps MGC131045, anticorps HVH2, anticorps MKP-2, anticorps MKP2, anticorps TYP, anticorps 2700078F24Rik, anticorps AI844617, anticorps BB104621, anticorps E130306H24Rik, anticorps Mkp-2, anticorps Mkp2, anticorps dual specificity phosphatase 4, anticorps dual specificity phosphatase 4 S homeolog, anticorps dusp4, anticorps DUSP4, anticorps dusp4.S, anticorps Dusp4

Sujet: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported.
Alias Symbols: HVH2, MKP-2, MKP2, TYP
Protein Interaction Partner: UBC, MAPK8, MAPK3, APP, CRMP1, GRIN1, MAPK9, GRIN2D, MAPK14, MAPK1,
Protein Size: 394

Poids moléculaire: 43 kDa

ID gène: 1846

NCBI Accession: NM_001394, NP_001385

UniProt: Q13115

Pathways: Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades