WISP2 anticorps (C-Term)

N° du produit ABIN2789751

Détail du produit anti-WISP2 anticorps

Antigène: WISP2 (WNT1 Inducible Signaling Pathway Protein 2 (WISP2))

Épitope: C-Term

Reactivité: Humain, Rat, Chien, Cheval, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp WISP2 est non-conjugé

Application: Western Blotting (WB)

Séquence: WGPCSTTCGL GMATRVSNQN RFCRLETQRR LCLSRPCPPS RGRSPQNSAF

Homologie: Dog: 79%, Horse: 79%, Human: 100%, Pig: 79%, Rat: 79%

Attributs du produit: This is a rabbit polyclonal antibody against WISP2. It was validated on Western Blot.

Purification: Affinity Purified

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 250 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur WISP2

Antigène: WISP2 (WNT1 Inducible Signaling Pathway Protein 2 (WISP2))

Autre désignation: WISP2 (WISP2 Produits)

Synonymes: anticorps MGC84196, anticorps WISP2, anticorps ccn5, anticorps CCN5, anticorps CT58, anticorps CTGF-L, anticorps Ccn5, anticorps Crgr4, anticorps Ctgfl, anticorps Rcop1, anticorps WNT1 inducible signaling pathway protein 2, anticorps WNT1 inducible signaling pathway protein 2 S homeolog, anticorps WISP2, anticorps wisp2.S, anticorps wisp2, anticorps Wisp2

Sujet: This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72 % identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover.
Alias Symbols: CCN5, CT58, CTGF-L
Protein Interaction Partner: HDAC3, HDAC1, IGF1R, IGF2R,
Protein Size: 250

Poids moléculaire: 24 kDa

ID gène: 8839

NCBI Accession: NM_003881, NP_003872

UniProt: O76076

Pathways: Signalisation WNT, Growth Factor Binding