MYSM1 anticorps (C-Term)

N° du produit ABIN2790657

Cet anticorps Lapin Polyclonal détecte spécifiquement MYSM1 dans WB. Il présente une réactivité avec des échantillons de Humain, Chien et Lapin.

Aperçu rapide pour MYSM1 anticorps (C-Term) (ABIN2790657)

Antigène: MYSM1 (Myb-Like, SWIRM and MPN Domains 1 (MYSM1))

Reactivité: Humain, Chien, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MYSM1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-MYSM1 anticorps

Épitope: C-Term

Fonction: MYSM1 Antibody - C-terminal region

Séquence: CLQKLLECMR KTLSKVTNCF MAEEFLTEIE NLFLSNYKSN QENGVTEENC

Homologie: Dog: 86%, Human: 100%, Rabbit: 77%

Attributs du produit: This is a rabbit polyclonal antibody against MYSM1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C-terminal region of Human MYSM1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP67188-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur MYSM1

Antigène: MYSM1 (Myb-Like, SWIRM and MPN Domains 1 (MYSM1))

Autre désignation: MYSM1

Sujet:

Background Information: MYSM1 is a metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. It preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. MYSM1 acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.

Alternative Symbols: 2ADUB, BMFS4, 2A-DUB

Protein Name: Histone H2A deubiquitinase MYSM1

Poids moléculaire: 91kDa

ID gène: 114803

NCBI Accession: NP_001078956

UniProt: Q5VVJ2

Pathways: Chromatin Binding