PLD6 anticorps (C-Term)

N° du produit ABIN2791346

Cet anticorps anti-PLD6 Polyclonal Lapin (ABIN2791346) détecte spécifiquement PLD6 dans WB. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour PLD6 anticorps (C-Term) (ABIN2791346)

Antigène: PLD6 (Phospholipase D Family, Member 6 (PLD6))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PLD6 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-PLD6 anticorps

Épitope: C-Term

Fonction: PLD6 Antibody - C-terminal region

Séquence: ITEDDEYVRL FLEEFERIWE QFNPTKYTFF PPKKSHGSCA PPVSRAGGRL

Homologie: Human: 100%

Attributs du produit: This is a rabbit polyclonal antibody against PLD6. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C-terminal region of Human PLD6

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP69458-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur PLD6

Antigène: PLD6 (Phospholipase D Family, Member 6 (PLD6))

Autre désignation: PLD6

Sujet:

Background Information: PLD6 is a cardiolipin hydrolase present at the mitochondrial outer membrane required both for mitochondrial fusion and piRNA metabolic process. PLD6 acts by catalyzing the hydrolysis of cardiolipin (diphosphatidylglycerol) to form phosphatidate (phosphatidic acid or PA) at the mitochondrial outer membrane surface, promoting mitochondrial fusion. The production of phosphatidate also regulates the piRNA metabolic process by promoting recruitment and/or activation of components of the meiotic nuage, also named P granule, a critical step for primary biogenesis of piRNAs. It is required during spermatogenesis to repress transposable elements and prevent their mobilization via its role in the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons.

Alternative Symbols: ZUC

Protein Name: Mitochondrial cardiolipin hydrolase

Poids moléculaire: 28kDa

ID gène: 201164

NCBI Accession: NP_849158

UniProt: Q8N2A8

Pathways: Ribonucleoprotein Complex Subunit Organization