NME1 anticorps (N-Term)

N° du produit ABIN2792090

Cet anticorps anti-NME1 Polyclonal Lapin (ABIN2792090) détecte spécifiquement NME1 dans WB, IHC et DB. L’anticorps est réactif avec des échantillons de Humain, Souris, Rat, Boeuf (Vache), Cheval, Lapin et Cobaye.

Aperçu rapide pour NME1 anticorps (N-Term) (ABIN2792090)

Antigène: NME1 (Non-Metastatic Cells 1, Protein (NM23A) Expressed in (NME1))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Cheval, Lapin, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NME1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Dot Blot (DB)

Détail du produit anti-NME1 anticorps

Épitope: N-Term

Fonction: NME1 Antibody - N-terminal region

Séquence: ANCERTFIAI KPDGVQRGLV GEIIKRFEQK GFRLVGLKFM QASEDLLKEH

Homologie: Cow: 100%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against NME1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human NME1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur NME1

Antigène: NME1 (Non-Metastatic Cells 1, Protein (NM23A) Expressed in (NME1))

Autre désignation: NME1

Sujet:

Background Information: This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product.This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product.

Gene Name: Non-metastatic cells 1, protein (NM23A) expressed in

Alternative Symbols: NB, AWD, NBS, GAAD, NDKA, NM23, NDPKA, NDPK-A, NM23-H1

Protein Name: Nucleoside diphosphate kinase B

Poids moléculaire: 17kDa

ID gène: 4830

NCBI Accession: NP_000260

UniProt: P22392

Pathways: Apoptose, Nucleotide Phosphorylation, Carbohydrate Homeostasis, Ribonucleoside Biosynthetic Process