Exportin 2 anticorps (N-Term)

N° du produit ABIN2792099

Cet anticorps anti-Exportin 2 est un anticorps Lapin Polyclonal détectant Exportin 2 dans WB. Adapté pour Humain, Souris, Rat, Boeuf (Vache), Chien, Lapin, Cheval, Porc et Poisson zèbre (Danio rerio).

Aperçu rapide pour Exportin 2 anticorps (N-Term) (ABIN2792099)

Antigène: Exportin 2 (CSE1L) (CSE1 Chromosome Segregation 1-Like (CSE1L))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Lapin, Cheval, Porc, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Exportin 2 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Exportin 2 anticorps

Épitope: N-Term

Séquence: ELSDANLQTL TEYLKKTLDP DPAIRRPAEK FLESVEGNQN YPLLLLTLLE

Homologie: Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against CSE1L. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human CSE1L

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 971 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur Exportin 2

Antigène: Exportin 2 (CSE1L) (CSE1 Chromosome Segregation 1-Like (CSE1L))

Autre désignation: CSE1L

Sujet: Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. CSE1L binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the protein may play a role both in apoptosis and in cell proliferation.Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CAS, CSE1, MGC117283, MGC130036, MGC130037, XPO2
Protein Interaction Partner: ERLIN2, HUWE1, UBC, FUS, SUMO2, STAU1, SUMO1, NEDD8, ASB16, RNF2, SUZ12, PDIA3, TBCB, CKB, GINS3, BCCIP, UBFD1, CNDP2, SCLY, CHORDC1, RRAGB, GDA, NPEPPS, SLC9A3R1, KYNU, TGM2, TCEA1, SMS, RPS6KA3, MVD, LDHA, FBXO6, YWHAQ, EGFR, UBD, PTMA, CLN3, HDAC6, MMS
Protein Size: 971

Poids moléculaire: 110 kDa

ID gène: 1434

NCBI Accession: NM_001316, NP_001307

UniProt: P55060

Pathways: Protein targeting to Nucleus