BIRC7 anticorps (Middle Region)

N° du produit ABIN2792130

L’anticorps anti-BIRC7 Polyclonal Lapin est utilisé pour la détection de BIRC7 dans des échantillons de Humain, Boeuf (Vache), Chien et Lapin. Il a été validé pour WB.

Aperçu rapide pour BIRC7 anticorps (Middle Region) (ABIN2792130)

Antigène: BIRC7 (Baculoviral IAP Repeat-Containing 7 (BIRC7))

Reactivité: Humain, Boeuf (Vache), Chien, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BIRC7 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-BIRC7 anticorps

Épitope: Middle Region

Fonction: BIRC7 Antibody - middle region

Séquence: EERTCKVCLD RAVSIVFVPC GHLVCAECAP GLQLCPICRA PVRSRVRTFL

Homologie: Cow: 85%, Dog: 84%, Human: 100%, Rabbit: 92%

Attributs du produit: This is a rabbit polyclonal antibody against BIRC7. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human BIRC7

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur BIRC7

Antigène: BIRC7 (Baculoviral IAP Repeat-Containing 7 (BIRC7))

Autre désignation: BIRC7

Sujet:

Background Information: BIRC7 protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits caspase-3 and proteolytic activation of pro-caspase-9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis.The protein encoded by this gene is a member of the family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Two transcript variants encoding different isoforms have been found for this gene. The two isoforms have different antiapoptotic properties, with isoform alpha protecting cells from apoptosis induced by staurosporine and isoform b protecting cells from apoptosis induced by etoposide.

Gene Name: Baculoviral IAP repeat containing 7

Alternative Symbols: KIAP, LIVIN, MLIAP, RNF50, ML-IAP

Protein Name: Baculoviral IAP repeat-containing protein 7

Poids moléculaire: 33kDa

ID gène: 79444

NCBI Accession: NP_647478

UniProt: Q96CA5