Cyclin D3 anticorps (CCND3) (C-Term)

Details for Product anti-CCND3 Antibody No. ABIN2792167
Antigène
  • zgc:103502
  • CCND3
  • 9230106B05Rik
  • AA682053
  • AL024085
  • AW146355
  • C78795
  • cyclin D3
  • ccnd3
  • CCND3
  • Ccnd3
Épitope
C-Term
51
42
24
17
15
10
7
3
3
3
2
2
2
2
2
2
2
1
Reactivité
Boeuf (Vache), Chien, Cobaye, Humain, Souris, Porc, Rat (Rattus), Mouton
227
153
135
10
4
3
2
1
1
1
1
Hôte
Lapin
203
44
Clonalité
Polyclonal
Conjugué
Cet anticorp Cyclin D3 est non-conjugé
12
8
8
6
6
6
5
5
5
5
5
5
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
160
84
62
36
26
19
19
14
12
8
5
2
1
1
1
1
1
1
1
Options
Immunogène The immunogen is a synthetic peptide directed towards the C terminal region of human CCND3
Séquence CQEQIEAALR ESLREASQTS SSPAPKAPRG SSSQGPSQTS TPTDVTAIHL
Homologie Cow: 100%, Dog: 100%, Guinea Pig: 92%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%, Sheep: 100%
Attributs du produit This is a rabbit polyclonal antibody against CCND3. It was validated on Western Blot and immunohistochemistry.
Purification Affinity Purified
Plasmids, Primers & others Plasmids, Primers & others Cyclin D3 products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation CCND3 (CCND3 Antibody Extrait)
Sujet CCND3 encodes a protein that belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation.
Protein Interaction Partner: POLR3GL, TFIP11, CDKN1A, CDK6, CDK4, CDK5, MCM10, CDKN1B, CDK2, CDK11B, FAS, SIL1, EIF3K, ATF5, VDR, MAPK6, NME1, MYB, GC, ETV1, RBL2, POLD1, CDK14, APP, RB1, UBC, PPP1CC, PPP1CB, PPP1CA, NCOA2, MAF1, NPDC1, DMTF1, CRABP2, RARA, DTNBP1, AKAP8, EFEMP2, CAS
Protein Size: 292
Poids moléculaire 33 kDa
ID gène 896
NCBI Accession NM_001760, NP_001751
UniProt P30281
Pathways Cycle Cellulaire, Mitotic G1-G1/S Phases, Glycosaminoglycan Metabolic Process
Indications d'application Optimal working dilutions should be determined experimentally by the investigator.
Commentaires

Antigen size: 292 AA

Restrictions For Research Use only
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Avoid repeated freeze-thaw cycles.
Stock -20 °C
Stockage commentaire For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Images (Fournisseur)
Western Blotting (WB) image for anti-Cyclin D3 (CCND3) (C-Term) antibody (ABIN2792167) WB Suggested Anti-CCND3 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Posi...
Immunohistochemistry (IHC) image for anti-Cyclin D3 (CCND3) (C-Term) antibody (ABIN2792167) Human Muscle
Western Blotting (WB) image for anti-Cyclin D3 (CCND3) (C-Term) antibody (ABIN2792167) Host: Mouse Target Name: CCND3 Sample Tissue: Mouse Spleen Antibody Dilution: ...
Immunohistochemistry (IHC) image for anti-Cyclin D3 (CCND3) (C-Term) antibody (ABIN2792167) Rabbit Anti-CCND3 Antibody AV Formalin Fixed Paraffin Embedded Tissue: Human Lymph N...
Background publications Pruneri, Valentini, Fabris, Del Curto, Laszlo, Bertolini, Martinelli, Leocata, Viale, Neri: "Cyclin D3 immunoreactivity in follicular lymphoma is independent of the t(6;14)(p21.1;q32.3) translocation or cyclin D3 gene amplification and is correlated with histologic grade and Ki-67 labeling index." dans: International journal of cancer. Journal international du cancer, Vol. 112, Issue 1, pp. 71-7, 2004 (PubMed).