RAB8A anticorps (Middle Region)

N° du produit ABIN2792290

Cet anticorps anti-RAB8A Polyclonal Lapin (ABIN2792290) détecte spécifiquement RAB8A dans WB. L’anticorps est réactif avec des échantillons de Humain, Souris, Rat, Chien, Boeuf (Vache), Porc, Mouton et Poisson zèbre (Danio rerio).

Aperçu rapide pour RAB8A anticorps (Middle Region) (ABIN2792290)

Antigène: RAB8A (RAB8A, Member RAS Oncogene Family (RAB8A))

Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Porc, Mouton, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RAB8A est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-RAB8A anticorps

Épitope: Middle Region

Fonction: RAB8A Antibody - middle region

Séquence: GIKFMETSAK ANINVENAFF TLARDIKAKM DKKLEGNSPQ GSNQGVKITP

Homologie: Cow: 100%, Dog: 100%, Human: 100%, Mouse: 85%, Pig: 100%, Rat: 85%, Sheep: 100%, Zebrafish: 85%

Attributs du produit: This is a rabbit polyclonal antibody against RAB8A. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human RAB8A

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur RAB8A

Antigène: RAB8A (RAB8A, Member RAS Oncogene Family (RAB8A))

Autre désignation: RAB8A

Sujet:

Background Information: RAB8A is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable.The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97 % , 96 %, and 51 % similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: RAB8A, member RAS oncogene family

Alternative Symbols: MEL, RAB8

Protein Name: Ras-related protein Rab-8A

Poids moléculaire: 24kDa

ID gène: 4218

NCBI Accession: NP_005361

UniProt: P61006

Pathways: M Phase, Regulation of long-term Neuronal Synaptic Plasticity, SARS-CoV-2 Protein Interactome