Retinoic Acid Receptor alpha anticorps (Middle Region)

N° du produit ABIN2792621

Cet anticorps Lapin Polyclonal détecte spécifiquement Retinoic Acid Receptor alpha dans WB et IHC. Il présente une réactivité envers Humain, Souris, Rat, Boeuf (Vache), Chien et Lapin.

Aperçu rapide pour Retinoic Acid Receptor alpha anticorps (Middle Region) (ABIN2792621)

Antigène: Retinoic Acid Receptor alpha (RARA) (Retinoic Acid Receptor, alpha (RARA))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Retinoic Acid Receptor alpha est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-Retinoic Acid Receptor alpha anticorps

Épitope: Middle Region

Séquence: EMLENSEGLD TLSGQPGGGG RDGGGLAPPP GSCSPSLSPS SNRSSPATHS

Réactivité croisée: Chien, Poulet, Humain, Souris, Rat (Rattus)

Homologie: Cow: 100%, Dog: 100%, Human: 100%, Mouse: 85%, Rabbit: 100%, Rat: 85%

Attributs du produit: This is a rabbit polyclonal antibody against RARA. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human RARA

Information d'application

Indications d'application: WB Suggested Anti-RARA Antibody Titration: 0.2-1 µg/mL
ELISA Titer: 1:312500
Positive Control: OVCAR-3 cell lysate.
Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 462 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur Retinoic Acid Receptor alpha

Antigène: Retinoic Acid Receptor alpha (RARA) (Retinoic Acid Receptor, alpha (RARA))

Autre désignation: RAR-alpha / RARA

Sujet: Retinoid signaling is transduced by 2 families of nuclear receptors, retinoic acid receptor (RAR) and retinoid X receptor, which form RXR/RAR heterodimers. In the absence of ligand, DNA-bound RXR/RARA represses transcription by recruiting the corepressors NCOR1, SMRT, and histone deacetylase. When ligand binds to the complex, it induces a conformational change allowing the recruitment of coactivators, histone acetyltransferases, and the basic transcription machinery.
Alias Symbols: NR1B1, RAR
Protein Interaction Partner: NCOR2, NCOR1, RXRG, MED1, HDAC1, NRIP1, TEKT4, NSD1, NCOA1, CEBPA, ITGB1BP2, SUMO1, UBC, MBD3, CBX5, MTA2, E2F1, WWOX, Sumo2, RXRB, RXRA, AKT1, MMS19, Dlg4, TMEM54, FN1, USP7, NCOA2, SUZ12, EZH2, PML, PSMC5, FAS, PRAM1, TBL1XR1, PRAME, ARID5A, UBE3A, UBQL
Protein Size: 462

Poids moléculaire: 51 kDa

ID gène: 5914

NCBI Accession: NM_000964, NP_000955

UniProt: P10276

Pathways: Nuclear Receptor Transcription Pathway, Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, S100 Proteins