TBP anticorps (Middle Region)

N° du produit ABIN184358

L’anticorps Lapin Polyclonal anti-TBP a été validé pour WB. Il convient pour détecter TBP dans des échantillons de Humain, Souris, Rat, Boeuf (Vache), Lapin, Poisson zèbre (Danio rerio), Chien, Mouton et Cobaye. Il y a 1 publication disponible.

Aperçu rapide pour TBP anticorps (Middle Region) (ABIN184358)

Antigène: TBP (TATA Box Binding Protein (TBP))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Lapin, Poisson zèbre (Danio rerio), Chien, Mouton, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TBP est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-TBP anticorps

Épitope: Middle Region

Séquence: FSSGKMVCTG AKSEEQSRLA ARKYARVVQK LGFPAKFLDF KIQNMVGSCD

Réactivité croisée: Boeuf (Vache), Chien, Poulet, Humain, Souris, Rat (Rattus)

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against TBP. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human TBP

Information d'application

Indications d'application: WB Suggested Anti-TBP Antibody Titration: 2.5 µg/mL
Positive Control: Human Placenta.
Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 339 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-TBP (ABIN184358)

Reid, van Roon-Mom, Wood, Rees, Owen, Faull, Dragunow, Snell: "TBP, a polyglutamine tract containing protein, accumulates in Alzheimer's disease." dans: Brain research. Molecular brain research, Vol. 125, Issue 1-2, pp. 120-8, (2004) (PubMed).

Détails sur TBP

Antigène: TBP (TATA Box Binding Protein (TBP))

Autre désignation: TBP (TATA-box-binding protein)

Sujet: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminal. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. Mutations that expand the number of CAG repeats encoding this polyglutamine tract, and thus increase the length of the polyglutamine string, are associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease.
Alias Symbols: HDL4, GTF2D, SCA17, TFIID, GTF2D1
Protein Interaction Partner: DR1, SSX2IP, GOLGA2, MEF2A, TAF8, GNG12, GNB2, UBC, UBE2I, TAF10, TAF5, HNF4A, E2F1, PAX5, TAF1A, TCEA1, RUVBL2, Abt1, GTF2A2, ICE2, tat, MED26, TBP, TAF6, TAF4, TAF1, SP1, TP53, SNAPC2, SNAPC1, MUC1, Taf1c, Taf1b, GTF2B, HCVgp1, AHR, TAF9B, BTAF1, TAF13,
Protein Size: 339

Poids moléculaire: 38 kDa

ID gène: 6908

NCBI Accession: NM_003194, NP_003185

UniProt: P20226

Pathways: Signalisation WNT